In the current study, our goal is to provide new liquid chromatographic assay and related substance procedures for a few medications. The chemistry of chromogenic reagents is the subject of this investigation. The general approach for creating new chromatographic techniques involves optimizing experimental conditions, including pH effects, reagent concentration and order, temperature and time monitoring during additions, solvent effects, color development and stability, and optical properties like selectivity, specificity, linearity, accuracy, precision, LOD& LOQ, and robustness. The development of novel analytical techniques for the detection of a few selected combination medicines is the main topic of the current study. Additionally, the work validates newly created procedures following ICH specifications and shows that they are appropriate