Objective: There is no huge number of studies conducted on impact of different diseases on renal function. This main point is considered for the conductance of our study and this help to people for further conductance of our studies and gives brief idea about prevalence and predominance of renal failure. To rule out diseases cause renal damage. To evaluate the types of renal damage are more predominant was explained based on drugs, diseases, age, sex, social habits. Methodology: A non-experimental prospective observational study was conducted in nephrology department suraksha hospital Andhra Pradesh. The study was carried out around 3 years total 1000 patients were included in the study based on diseases, age, sex, social habits. Results and Key Finding: According to data the patient with age groups 50 to 70 were highly affected and age group >70 is less affected. Gender wise distribution of patients affected with renal failure is total 1000 patients was diagnosed renal damage out of which 600(60%) were males and 400(40%) were female. Area wise distribution of patient with renal failure out of 1000 patients 625 belong to rural area where as 375 belongs to urban area. In this study by the above information NSAIDS are more responsible for kidney failure when compared to the other drugs. Conclusion: Our study concluded and reports diseases alter kidney function. Diseases effect on kidney function more prone to males which is highly significant to the age group of 50 to 70 years. Untreated diabetes millitus damages the kidney function. A non-steroidal anti-inflammatory drug that belongs to analgesic category shows a higher significance in causing Kidney Damage among those drugs ibuprofen.