Purpose: The purpose of the study is to assess the incidence of people using medication in diabetes mellitus with comorbid conditions and to achieve the therapeutic goals by the effective patient counselling. Background: Diabetes mellitus is a condition caused due to the lack of insulin secretion to send the glucose from blood stream to cells. General process of diabetes occurs when the food turns into energy which is also called as glucose. These glucose molecules canz be released into bloodstream and higher levels of glucose inblood stream causes diabetes mellitus or high blood sugar. In this process, the pancreas release a hormonecalled insulin which is used to send the glucose molecules from blood stream to cells to avoid DM. Methodology: It is prospective observational study conducted in all the super specialities hospital in guntur. In this200patients with diabetes mellitus were selected for the study to evaluate the different types medications used in diabetes mellitus with comorbid conditions and the effect of patient counselling on patient health. Results and discussion: A total number of 200 patients were enrolled in the study. Among them 45% were female sand 55%were males of different age groups ranging from 21-60 years. It was found that 25% of them use Insulin therapy, 25% use combination of Oral Hypo glycemics along with Insulin, 25%of the patients use combination of Oral HypoglycemicsandSulfonylureas.Outof200patients who were provided with patient counselling, 120 patients showed improvement. Conclusion: According to the study, it was found that the us age of Insulin, combination of Oral hypo glycemic and Insulin, combination of Oral hypo glycaemic and Sulfonylureas was predominant.