Laparoscopic cholecystectomy is generally performed by inflating the tummy with carbon dioxide gas to permit the organs and structures within the tummy to be viewed so that the surgery can be performed. The present study was conducted to compare low pressure and standard pressure CO2 pneumoperitoneum during laparoscopic cholecystectomy. Materials & Methods:58 patients with uncomplicated symptomatic cholelithiasis of both genders were divided into 2 groups of 29 each. Group I was standard pressure pneumoperitoneum and group II was low pressure pneumoperitoneum group. Parameters such as duration of surgery, intra-operative gas consumption, post-operative shoulder tip pain (NPRS Score) in 1st 6 hours and mean arterial pressure (mm of hg) was recorded. Results: Group I had 10 males and 19 females and group II had 11 males and 18 females. Duration of surgery (mins) was 52.4 and 54.8, surgical field visualisation difficulty was seen in 6 and 10, intra-operative gas consumption (litres) was 110.4 and 103.5, bile spillage was seen in 4 and 7, drain was used in 9 and 12, post-operative shoulder tip pain (NPRS Score) in 1st 6 hours was 4.5 and 3.1 and mean arterial pressure (mm of hg) was 1.2 and 0.94 in group I and group II respectively. The difference was significant (P< 0.05). Conclusion: Laparoscopic cholecystectomy in low pressure pneumoperitoneum at 10 mm of hg pressure is safe and feasible.