Drug related problems (DRP) are any unenviable experiences of the patient which intervene the drug therapy and involves in the desired patient outcome. To curb the drug related problems, few vigilant steps can be taken which can preclude at least 50% of the total DRP related admissions (8.36%). In the present investigation, total 240 cases, where a correlation between past medication history and current complaints that resulted in hospitalization was established, were included in the 6 months prospective study done in departments of general medicine, dermatology, paediatrics and gastroenterology in tertiary care teaching hospital. Patient with no correlation between past medication history and current complaints, social habits causing hospitalization, herbal medication use history were excluded. The results revealed that nonadherence (51.07%) and ADR (38.21%) are predominant among the identified drug-related problems. Moreover, both paediatrics and geriatric patients showed the higher incidence of non-adherence to the prescribed therapy. Interestingly, majority of the adults showed adverse drug reactions (ADRs) as the DRP with higher incidence, followed by non-adherence to the prescribed therapy. Lack of knowledge about the disease, its complications and possible adverse reactions with self-medication was identified to be the high incidence risk factor. Higher incidence of drug-related problems was observed in patients having past medical history of CVS and CNS diseases which require long-term management.