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ISSN 2063-5346
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A PROSPECTIVE INTERVENTIONAL STUDY ON COMBINATION OF CALCIUM CARBONATE AND VITAMIN D3 IN OSTEOPOROSIS PATIENT – AN OPEN LABELLED TRIAL

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Vijayakumar S 1 , Parimalakrishnan S 2 , Vijayakumar AR3 , Yeshwanthkumar B4
» doi: 10.31838/ecb/2023.12.s1-B.278

Abstract

Background: Globally, Calcium and vitamin D 3 are widely used therapies for osteoporosis patients. However, addition of supplements to improve strengthens their bones, and reduced bone-related deficiencies such as osteopenia and osteoporosis. Though the effectiveness of these supplements may prove evidences of strengthen to the existing therapies. Objective: This study aimed to assess before and after intake of calcium carbonate and vitamin D3 combination drugs among osteoporosis patients. Methodology: The study group consist of 137 subjects from district headquarters hospital of Krishnagiri, Tamil Nadu. From these, 80 subjects with low level of ‘T’ score value (< -1.0 SD) were enrolled in the study population and they were administered with calcium (500mg) and Vit D3 (250I/U) day-1 for the period of 18 weeks. At the end of the treatment ‘T’ scores were recorded in all patients, before and after study period. In addition to that patient’s relevant data were collected through personal interview method. Results: Before intervention prevalence of osteopenia and osteoporosis were found to be 33.7 % and 66.3 % respectively. Among study subjects 60 completed 18 week period of drug treatment, reported improvement of bone mineral density significantly (‘p’ <0.0001). In study group 60% subject fully recovered from osteoporotic to osteopenic condition. The data reports base line characteristics revealed that high risk features of osteoporosis was observed in both groups of smokers and alcohol consumption study subjects were found to be 11.6 % and 60 % respectively. Conclusion: The present study highlighted that intake of calcium supplements increase bone mineral density and however, decreases in risk of osteoporosis condition targeting these groups.

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