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ISSN 2063-5346
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A prospective, double-blinded, placebo-controlled study assessing effectiveness of intraoperative periarticular cocktail injection for pain control and knee motion recovery after total knee replacement

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Dr. Shiva Naik R, Dr. Basavaraj Shetkar, Dr. Abhilash S, Dr. Balagangadhara Choudhary V
» doi: 10.31838/ecb/2023.12.si6.114

Abstract

The aim of the present study was to evaluate the benefits of a particular cocktail combination in patients undergoing TKR with respect to pain and knee motion recovery. Methods: A prospective, double-blinded, placebo-controlled trial included patients who underwent simultaneous bilateral TKR in the duration of 18 months in the institute. 200 consecutive patients who satisfied the inclusion criteria were selected for the study. All the patients had a full understanding of the 10-point visual analog pain scale (VAS). Results: When compared with the control knee, a statistically significant reduction in pain score was noted in the cocktail injected knee at 6, 12, 24 and 48 hours (P < .001 in all cases). However, the difference in the mean pain scores between both knees at the third (P =.675) and fourth (P = .220) days were not significant. Within the intervention group, there was a significant difference in the pain scores over different time points. A post hoc analysis showed no significant difference within various time points on the first day (6, 12, and 24 hours) after surgery. However, a statistically significant difference in the pain scores was noted at 48 hours (P < .001), 72 hours (P < .010) and 96 hours (P < .001), compared with the 24-hour score. Within the control group, there was a significant difference in pain scores over different time points. However, a post hoc analysis showed that there was no significant difference within various time points on the first day (6, 12, and 24 hours) after surgery, and statistically significant improvement was found only after 72 hours (P < .001) and 96 hours (P < .001), compared with the 24-hour value. Conclusion: The use of intraoperative periarticular cocktail injection significantly reduces early postoperative pain and provides better early knee motion

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