The simultaneous measurement of ivermectin and albendazole by RP-HPLC method has been established as a new unique method. The chromatogram conditions were successfully generated utilising an ACE C18 column (4.6150mm) 5, a flow rate of 1.2 ml/min, a mobile phase of (70:30 v/v) methanol: phosphate buffer pH 3 (pH was altered with ortho phosphoricacid), and a lamba max of 240nm. WATERS HPLC Sampler and a PDA detector are the tools utilised. 2.3 and 3.3 minutes were discovered to be the RT. Ivermectin and albendazole were found to be respectively 101.3% and 99.9% pure. The resolution was 6.0, and the system suitability parameters for ivermectin and albendazole were determined to be 4668, 1.3, and 6089, and 1.2, respectively. The analytical technique was ICH-validated