Context: According to Ayurveda, Vyanga is one of the diseases mentioned under Kshudraroga and is, also considered as a svatantra vyadhi. Maharshi Charaka and Susruta both have considered Vyanga as raktajaroga. Thus Vyanga is a painless condition for body but it is painful for mind. Aim: Present study was intended to assess the association between raktadustikara nidana and Vyanga. Methods: A nidanatmaka study was conducted at NIA Jaipur in which 200 subjects of Vyanga were included after informed consent and data were collected to assess the association between raktadustikara nidana and Vyanga. Results: It was found that 34.16% patients were taking raktadustikara nidana in the current nidanatmaka survey. Conclusion: In this study it was concluded that there is some association between the raktadustikara nidana and Vyanga. So Vyanga can be corrected by treating as a raktapradoshaja vikara