Monosodium glutamate (MSG), a commonly used flavour enhancer, in almost all savory foods. However, there are still unanswered health-related problems surrounding MSG use in humans. Research suggests that MSG is the root cause of a number of diseases, including obesity, the Chinese syndrome disorder, redox imbalance, and adverse effects on reproduction. Similarly, additional clinical research contradicts MSG's unfavorable health effects and demonstrates its positive effects on issues like appetite, salt intake, and bone development, etc. This article reviews the research on the beneficial and harmful effects of MSG on homo sapiens. MSG was regarded as safe by the WHO, US FDA, United Nations Food and Agriculture Organization, and many other regulatory bodies, although it shouldn't be consumed in amounts that exceed.