Background: In cirrhotic patients, the bacterial infection is associated with a poor prognosis yet might present with several diagnostic challenges. In patients with liver cirrhosis, the significance of clinical measures such as neutrophil count, leukocyte count, systemic inflammatory response syndrome, and other markers is still unknown. Aim: The purpose of this study was to assess the use of inflammatory indicators and identify the most effective markers for the identification of infection in patients with decompensated cirrhosis. Methods: This study was conducted at Nishtar Hospital Multan and the duration of this study was from August 2022 to July 2023. The presence of infection was evaluated. Markers of infection consist of leukocyte count, neutrophil count, neutrophil to lymphocyte ratio (NLR), C-reactive protein (CRP) and resistin were measured. Accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were determined. Results: Spontaneous bacterial peritonitis (SBP) was the most prevalent kind of illness, affecting twenty individuals (or 25%). The group with bacterial infections had greater levels of NLR, CRP, and resistin (p < 0.05). CRP and resistin were found to be predictive factors for the incidence of bacterial infections, according to multiple logistic regression analyses (p < 0.05). Baseline CRP, with a cut-off value of 11.65 mg/L, and resistin, with a cut-off value of 13 ng/mL, produced area under the receiver operating characteristic (ROC) curves of 0.796 and 0.787, respectively, for the diagnosis of infection. For CRP, the corresponding values were 90%, 73%, 52.9%, and 95.7% for sensitivity, specificity, PPV, and NPV. The corresponding values for resistin's sensitivity, specificity, PPV, and NPV were 90%, 59%, 41.9%, and 94.6%. Conclusions: According to this study, resistin and CRP have moderate to high accuracy in diagnosing bacterial infections in liver cirrhosis.