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ISSN 2063-5346
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“A CROSS SECTIONAL STUDY TO EVALUATE PULMONARY DYSFUNCTION IN PATIENTS WITH METABOLIC SYNDROME BY PULMONARY FUNCTION TESTS.”

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Gaurav S. Shinde, Virendra C. Patil
» doi: 10.31838/ecb/2023.12.si4.172

Abstract

Background: Metabolic syndrome is a combination of various metabolic diseases which further leads to pulmonary dysfunction. The major features of metabolic syndrome includes central obesity, insulin resistance, hypertension, dyslipidaemia, high Triglycerides and low HDL levels. To evaluate this we studied the pulmonary function tests by spirometry in patients with metabolic syndrome and to find relation of spirometric parameters (FVC, FEV1, FEV1/FVC ) with metabolic syndrome. Methods: This was a single centre hospital-based cross-sectional, observational, descriptive study conducted in subjects admitted to the General Medicine Ward of our institute over a period of 18 months from October 2020 to March 2022. Pulmonary function tests were carried out on patients with metabolic syndrome by spirometer and were observed for pulmonary dysfunction. Results: Mean age was 53.6+ 14.4 years ranging from 22 to 85 years. Mean systolic blood pressure was 132.7 (+17.3) and mean diastolic blood pressure was 80.9 (+9.8) mm of Hg. Mean serum triglyceride level was 255.9 (+142.5). Mean high density lipoprotein was 38.1 (+11.7). Mean fasting blood sugar was 178.2 (+97.5). On pulmonary function test category, majority 45.1% had restrictive pattern. Association between metabolic syndrome component and FEV1, showed that as metabolic syndrome component increases, FEV1 also increases. (‘p’ = 0.17). Association between metabolic syndrome component and FVC, showed that as metabolic syndrome component increased FVC decreased and shows statistical significance. (‘p’ = 0.04). Association between metabolic syndrome component and FEV1/FVC showed that as metabolic syndrome component increased ratio also increased and shows statistical significance. (‘p’= 0.0002) Conclusion: In the present study we observed that increasing components of metabolic syndrome had significantly impaired pulmonary functions. It was observed that, as the components of metabolic syndrome increased, severity of pulmonary dysfunction also increased. To conclude, increasing components of metabolic syndrome have significant impairment of the pulmonary function.

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