Background: The term prolapsed disc means the protrusion or extrusion of the nucleus. One of the main causes of low back pain is degenerative disc disease in the lumbar spine. The protrusion or extrusion of the nucleus is referred to as a prolapsed disc. It is a series of changes in the disc, not a single event, that eventually cause it to prolapse. It is a spinal disorder that can result in lower back discomfort, as well as numbness, muscle tightness, pins and needles, and a sense of muscle weakening. Objective: The study aims to assess the effect of core strengthening exercise versus McKenzie exercise in patients with PIVD (lumbar spine) through VAS score. Methods: This Experimental comparative study was carried out after the approval of Pacific Medical University, Institute‘s ethical approval obtained dated 06/09/2022, PMU/ PMCH/IEC/2022/228. All participants completed information and consent form at recruitment. 30 subjects were selected according to inclusion and exclusion criteria and divided into 2 groups of 15 subject each randomly. The Group A subject received McKenzie extension exercise and the group B subject received Core strengthening exercise. Both the group were treated for 6 weeks. For six weeks, both groups received treatment five times each week. On the first day of every week until the conclusion of the six weeks, patients were assessed using the VAS score. Results: According to this study, patients with prolapsed intervertebral discs (Lumbar spine condition) respond better to core strengthening exercise than McKenzie extension exercise in terms of pain relief, muscle strength, and functional performance. Conclusion: The present study's statistical analysis revealed that the core strengthening exercise regimen was extremely successful in treating low back pain associated with prolapsed intervertebral discs (Lumbar spine) condition. It is effective in reducing pain and functional impairment as a therapy strategy.