Herbal remedies have become an integral part of our medical system to treat illness. Because of the medicinal plants' low risk of side effects, high efficacy and safety, researchers around the world are utilizing these plants. However, there are still many medicinal plants with powerful remedies which are yet to be explored. This tempted the researchers to validate scientifically various folklore uses so that they can be beneficial to mankind. One of these plants, Hemigraphis colorata (H. colorata) plays a significant role in the medical care system and has had a notable impact on the remedy of traditional diseases. Bloody diarrhea, haemorrhoids, wound healing, bacterial infections, and fungal infections have all been treated with this herb. In addition to these, numerous pharmacological investigations indicate that the plant also possesses strong antibacterial, antiinflammatory, anticancer, anti-diabetic, anti-diarrheal, and other biological effects. Such widespread biological activities may be attributed to the diverse phytochemicals present including alkaloids, glycosides, steroids, tannins and flavonoids. The goal of the current review is to compile all information related to the plant under consideration which can be helpful to the researchers for further validation of folklore use.