Background: Finding an effective treatment for PDAC has been a difficulty. Since surgical resection for PDAC is characterized by a high rate of morbidity and subsequent recurrence, a multimodal approach to PDAC management is recommended to improve both the expectancy and quality of life. Objective: The present study aims to summarize current evidences comparing perioperative and oncological outcomes between MIPD and OPD for PDAC. Methods: The current study is a systematic review article. Data were collected between 1 December 2021 and 30 February 2022. Medline and PubMed public database searches will be carried out for papers written all over the world on comparing MIPD and OPD for PDAC. The keyword search headings included “Minimally Invasive, Open, Distal,Pancreatectomy, Resectable Pancreatic Ductal Adenocarcinoma", and a combination of these were used. For additional supporting data, the sources list of each research was searched. Results: PDAC accounts for high percentage of cancer-related mortality.It shows resistant to chemotherapy which necessities surgical intervention. Minimally invasive distal pancreatectomy(MIDP) and Open Distal Pancreatectomy are the two main surgical interventions in the management of PDAC. Many researches reported the shift to MIDP due to many reasons such as less operative time and hospital stay time and less bleeding incidence. On the other hand ODP reported higher tumor size and high incidence of vessel resection. All the previously mentioned results indicates that MIDP is a promising management technique with more advantages than ODP. Conclusion: MIDP is a promising management technique with more advantages than ODP.