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ISSN 2063-5346
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A COMPARATIVE STUDY OF SERUM URIC ACID,C REACTIVE PROTEIN AND SERUM CALCIUM IN PREECLAMPTIC AND NORMOTENSIVE PREGNANT WOMEN.

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Dr. Anurag Gundi, Dr. Somnath Salgar
» doi: 10.31838/ecb/2023.12.si5.072

Abstract

Background: The Absence Of Reliable Biochemical Markers That Can Accurately Diagnose Preeclampsia Is Mostly To Blame For The Poor Maternal And Perinatal Outcomes In Preeclampsia Patients. In This Study, We Aimed To Find The Association Of Serum Uric Acid, C- Reactive Protein And Serum Calcium With Preeclampsia. Methodology: Prospective Case Control Study Was Conducted In B J Medical College And Sassoon General Hospital, Pune Over 12 Months. Total 76 Antenatal Women Of >24 Weeks Of Gestation With 38 Cases Having Preeclampsia And 38 Normotensive Females Were Enrolled And Were Compared For Maternal Uric Acid, Calcium Levels And C Reactive Protein. Independent Sample T Test Was Used To Compare Averages And Roc Analysis Was Done For Prediction Of Preeclampsia. Result: The Mean Value Of Crp (7.6 ±1,2 Mg/L), Serum Uric Acid (8.75±1.38 Mg/Dl) Was Significantly Higher In The Preeclamptic Group Whereas Serum Calcium In The Preeclamptic Women Was Significantly Lower (7.45±1.5 Mg/Dl ) Compared To The Normotensive Women <0.001). AUC For Uric Acid Was (0.853) (P<0.001) And It Was Found 73.3 % Sensitive And 87.7% Specific. AUC For Serum Calcium Was (0.809) (P<0.001) And It Was Found 76.1 % Sensitive And 93.1% Specific. AUC For All Three Parameters Taken Together Was Found 0.919 (P<0.001) And It Was Found 100 % Sensitive And 86.4% Specific In Prediction Of Preeclampsia. Conclusion: Maternal hyperuricemia, high CRP and hypocalcaemia were associated with preeclampsia. all three biochemical markers taken together showed highest accuracy in prediction of preeclampsia

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