Schizophrenia is a chronic debilitating illness characterized by delusions, hallucinations, disorganized speech, grossly disorganized behavior/catatonic symptoms and negative symptoms. Etiologically, Genetic factors, biochemical factors, neuro-pathological factors and environmental factors are important. Incidence of substance use is higher in patients suffering from psychotic conditions than in general population. Nicotine is the most common substance that is consumed by patients of schizophrenia. There is increased incidence of smoking in patients suffering from positive symptoms of schizophrenia to reduce the distress caused by delusions and hallucinations as per the well documented ‘Self-medication’ hypothesis in schizophrenia