The goal of this study is to examine the differences and similarities between mass closure and layered closure of midline laparotomy wounds. Material and methods: This research included a total of 100 different patients. Mass closure was performed on fifty patients, and layered closure was executed on the remaining fifty patients. Midline vertical incisions, the number of elective laparotomies performed, and the percentage of PDS suture material used were all similar between the two groups. Results: The age group beyond 60 years (31%) was shown to be the most susceptible in this research, followed by the age group below 30 years (22%). There were 64 male patients and 36 female patients out of a total of 100, making the female to male ratio 1.77:1. In this particular research, incisions made both above and below the midline were used most often. The mean amount of time needed to close a wound is longer in the layered closure group, which is statistically significant when compared to mass closure. As compared to layered closure, mass closure is the most cost-effective option. The incidence of early and late problems is somewhat higher in the multilayer closure group as compared to the mass closure group; however, this difference is not statistically significant. Conclusion: As compared to layered closure, the mass closure technique is a more costefficient, safe, and successful approach for closing midline laparotomy wounds. It also requires less time to complete than layered closure, which is linked with less post-operative problems.