Acute pancreatitis (AP) is a common disease with varying severity. The present study was conducted to compare low molecular weight heparin and conventional treatmentin the management of acute pancreatitis. Materials & Methods:80 patients of acute pancreatitis of both genders were randomly divided into 2 groups of 40 each. Group I patients underwent conventional therapy and group II patients were managed with administering low molecular weight heparin (LMWH) 1 mg/kg twice daily from admission until day 7 by subcutaneous injection. Parameters such as mean duration of stay, APACHE II scores on admission and at 1 week after treatment was determined. Results: Group I had 17 males and 23 females and group II had 18 males and 22 females. Group I had 9.2 days and group II had 12.3 day of hospital stay. The difference was significant (P< 0.05). The mean APACHE in group I and group II, at admission was 0-5 seen in 5% and 14%, 6-10 in 45% and 32%, 11-15 in 20% and 28% and 16-20 in 30% and 26%. At day 7 was 0-5 seen in 56% and 23%, 6-10 in 24% and 37%, 11-15 in 15% and 30% and 16-20 in 5% and 10% respectively. The difference was significant (P< 0.05). 95% in group I and 100% in group II recovered whereas 5% in group I died. The difference was significant (P< 0.05).