The matter of anxiety and depression is associated with the psychological behavior of humans. It is well known that desires and abilities are important determinant factors of human behavior. It is found that there is a significant impact of pure anxiety and pure depression on cognitive and personality measures of behavior. Additionally, the study's findings show that attitudes, norms, cognition and cultural perception are important determinant factors behind the driving of pure anxiety and pure depression on different cognitive personality measures. These consequences give a significant role in the building capacity of measurement of human behavior in the sense of psychology. Therefore, this study gives an understanding of rethinking and redefining phenomena of pure anxiety and pure depression in the psychological behavior of humans. Apart, this study would encourage policymakers, researchers, and students to further research the area of pure depression and pure anxiety in psychology.