Objective: A comparative research study on the effects of different Allium sativum bulb extracts on alloxaninduced diabetes mellitus The chloroform, acetone, ethanol, and aqueous extracts were prepared by macerating the bulbs of Allium sativum. The diabetic potential of the different extracts was evaluated by injecting Alloxan (150 mg/kg body weight) in a single dose into Wistar rats. The animals were divided into six groups, containing six rats in each group (non-diabetic group, diabetic group, and Allium sativum-treated groups). The extracts were administered orally at 100 mg/kg body weight to the diabetic rats for 14 days. The fasting blood glucose levels were measured, and histopathological studies were carried out. The administration of ethanolic, chloroform, aqueous, and acetone extracts of Allium sativum showed decreased necrotic lesions and perivascular edema compared to diabetic control rats. However, it was found to be greater in the aqueous extract. The current study concludes that administration of an aqueous extract of Allium sativum in rats attenuates fasting blood glucose significantly as compared to other extracts.