Background: Diabetes mellitus is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time which is seen worldwide. In past years Syzygium cumini has been used for the treatment of diabetes. Method: The current work, In-silico study was carried out by molecular docking using Argus lab on four 2ath, 5y7h, 5qij, receptors. Results: In the present work, we have completed molecular docking and as a conclusion we have further findings such as, when the docking of gallic acid, ferullic acid, egallic acid and myricetin acid was performed the result found ferullic acid is -10.27 and in reference ligand pioglitazone was found -12.53. Afterwards there was comparison study of test ligand and reference ligand was done and shows that there is protein binding with amino acid. In 2D structure hydrogen bonding is visible along with conventional hydrogen bond and vander-wal interactions. Conclusion: The result of this investigation shows that Syzygium cumini was found the potential to inhibit the diabetes mellitus.