ISSN 2063-5346
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Dr. Meenu gupta, Dr. Neha Sethi, Dr Maneesh Vijayvargiya, Dr. Manju Raghava, Dr Abha Mathur
» doi: 10.53555/ecb/2023.12.Si13.212


Background: Malignant Melanoma (MM) is an aggressive and most common lethal tumour of melanocytic origin. It represents less than 5 % of all cutaneous malignancies and accounts for majority of skin cancer deaths. The aim is to determine the clinicopathological features of MM and find a correlation between clinical and epidemiological factors with the different histomorphological parameters of the melanocytic tumours. Material And Methods: This study was carried out at Mahatma Gandhi Medical College, Jaipur, India from July 2022 to December 2022. 20 consecutive cases diagnosed histopathologically with or without IHC as MM were included in the study. Various histopathological parameters were studied which include cell shape, invasion (based on Clark’s system), presence of pigment, mitotic activity and dermal lymphocytic infiltration. Histopathological reporting was done as per CAP protocol and AJCC recent guidelines for resected specimen. Results: Out of the total cases, 13(65%) were cutaneous and 7(35%) were non cutaneous melanoma. The most common age group was sixth decade with female predominance. Among non-cutaneous melanomas, 4 were in anorectum, 2 in breast and 1 in bladder. The acral lentiginous type was the most common variety with foot being the most common region. Clarks level III and IV was the most common level of invasion which presented at stage T3. Conclusion: Lower extremity was the most common site amongst cutaneous melanomas. Tumour in lower extremities was more related with higher chance of metastasis. Anorectum being the most common site amongst non-cutaneous melanomas, presented with metastasis to colon.

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