Oxadiazole is a principal heterocyclic compound containing one oxygen and two nitrogen atoms in the five membered ring. 1,3,4-oxadiazole is a multifaceted heterocyclic moiety plays a major role in the pharmaceutical chemistry and broad range of important biological activities gain the attention of researchers to explore the new therapeutic molecule. The present review analyses the various synthetic procedures and pharmacological activities of 1,3,4-oxadiazole moiety