E-ISSN 2063-5346
 

Original Article 


THE EFFECTS OF ACUTE SUPPLEMENTATION OF EURYCOMA LONGIFOLIA (TONGKAT ALI) ON THE PREVENTION OF ETHANOL-INDUCED GASTRIC ULCER IN RATS

Masro Mohamad, Yasmin Ismail.

Abstract
This study was done to investigate the prevention of ethanol-induced ulcer of Eurycoma longifolia (E. Longifolia). E.
longifolia aqueous extract was obtained from a commercialised product (Nu-Prep Lelaki). A total of 36 rats (n=6 for each group)
which were separated into 6 groups were used in the present study. All rats were fasted from food for 24 hours prior to the pretreatment. For pre-treatment, Group 1 (normal group) and Group 2 (negative control group) received 0.9% normal saline, Group 3
(positive control group) received 150 mg of ranitidine, Group 4 (low dose group), Group 5 (intermediate dose group) and Group 6
(high dose group) each received 250 mg/kg, 500mg/kg and 1000mg/kg of E. longifolia respectively. Rats from Group 2, Group 3,
Group 4, Group 5 and Group 6 were induced with ulcers by administration of 5 ml/kg of absolute ethanol an hour after the pretreatment. The rats were euthanized an hour after ulcer induction. The stomachs were weighed and the degree of ulcerations was
scored. The mean ulcer score for Group 2 was found to be the highest (3.83) followed by Group 4 (1.83), Group 3 (1.5), Group 5
(0.83), Group 6 (0.33) and Group 1 (0). The mean ulcer score of Group 2 is significantly higher (p<0.05) when compared to the
mean ulcer score of other groups. Mean ulcer score of stomachs of rats from Group 5 and 6 scored lower when compared to Group
3 and this suggests that Group 6 with the highest dose is the most effective dose. The relative organ weight (ROW) of Group 2 was
the highest (0.75%) and is significantly higher (p<0.05) when compared to other groups. This is followed by Group 1 (0.64%),
Group 4 (0.59%), Group 3 and Group 6 scores the same (0.58%) and the lowest is Group 5 (0.56%). In conclusion, E. longifolia
extract can be used to prevent gastric ulcers and is comparable to ranitidine. However, further studies should be done to elucidate
the effects especially on histological evidence.

Key words: Eurycoma longifolia, E. Longifolia, gastric ulcer, peptic ulcer, ethanol-induced ulcer, anti-ulcer effects, protective effects against ulcer


 
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Pubmed Style

Masro Mohamad, Yasmin Ismail. THE EFFECTS OF ACUTE SUPPLEMENTATION OF EURYCOMA LONGIFOLIA (TONGKAT ALI) ON THE PREVENTION OF ETHANOL-INDUCED GASTRIC ULCER IN RATS. ECB. 2022; 11(10): 18-24. doi:10.31838/ecb/2022.11.10.004


Web Style

Masro Mohamad, Yasmin Ismail. THE EFFECTS OF ACUTE SUPPLEMENTATION OF EURYCOMA LONGIFOLIA (TONGKAT ALI) ON THE PREVENTION OF ETHANOL-INDUCED GASTRIC ULCER IN RATS. https://www.eurchembull.com/?mno=127185 [Access: November 29, 2022]. doi:10.31838/ecb/2022.11.10.004


AMA (American Medical Association) Style

Masro Mohamad, Yasmin Ismail. THE EFFECTS OF ACUTE SUPPLEMENTATION OF EURYCOMA LONGIFOLIA (TONGKAT ALI) ON THE PREVENTION OF ETHANOL-INDUCED GASTRIC ULCER IN RATS. ECB. 2022; 11(10): 18-24. doi:10.31838/ecb/2022.11.10.004



Vancouver/ICMJE Style

Masro Mohamad, Yasmin Ismail. THE EFFECTS OF ACUTE SUPPLEMENTATION OF EURYCOMA LONGIFOLIA (TONGKAT ALI) ON THE PREVENTION OF ETHANOL-INDUCED GASTRIC ULCER IN RATS. ECB. (2022), [cited November 29, 2022]; 11(10): 18-24. doi:10.31838/ecb/2022.11.10.004



Harvard Style

Masro Mohamad, Yasmin Ismail (2022) THE EFFECTS OF ACUTE SUPPLEMENTATION OF EURYCOMA LONGIFOLIA (TONGKAT ALI) ON THE PREVENTION OF ETHANOL-INDUCED GASTRIC ULCER IN RATS. ECB, 11 (10), 18-24. doi:10.31838/ecb/2022.11.10.004



Turabian Style

Masro Mohamad, Yasmin Ismail. 2022. THE EFFECTS OF ACUTE SUPPLEMENTATION OF EURYCOMA LONGIFOLIA (TONGKAT ALI) ON THE PREVENTION OF ETHANOL-INDUCED GASTRIC ULCER IN RATS. European Chemical Bulletin, 11 (10), 18-24. doi:10.31838/ecb/2022.11.10.004



Chicago Style

Masro Mohamad, Yasmin Ismail. "THE EFFECTS OF ACUTE SUPPLEMENTATION OF EURYCOMA LONGIFOLIA (TONGKAT ALI) ON THE PREVENTION OF ETHANOL-INDUCED GASTRIC ULCER IN RATS." European Chemical Bulletin 11 (2022), 18-24. doi:10.31838/ecb/2022.11.10.004



MLA (The Modern Language Association) Style

Masro Mohamad, Yasmin Ismail. "THE EFFECTS OF ACUTE SUPPLEMENTATION OF EURYCOMA LONGIFOLIA (TONGKAT ALI) ON THE PREVENTION OF ETHANOL-INDUCED GASTRIC ULCER IN RATS." European Chemical Bulletin 11.10 (2022), 18-24. Print. doi:10.31838/ecb/2022.11.10.004



APA (American Psychological Association) Style

Masro Mohamad, Yasmin Ismail (2022) THE EFFECTS OF ACUTE SUPPLEMENTATION OF EURYCOMA LONGIFOLIA (TONGKAT ALI) ON THE PREVENTION OF ETHANOL-INDUCED GASTRIC ULCER IN RATS. European Chemical Bulletin, 11 (10), 18-24. doi:10.31838/ecb/2022.11.10.004