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ISSN 2063-5346
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Therapeutic Potential of Polyphenols and Flavonoids for Asthma: A Structural Activity and Mechanistic Perspective

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Dr. Vibhor Kumar Jain, Dr. Bindu Jain, Dr. Rita Mourya, Dr. Ranjana, Dr. Neelesh Dwivedi, Anita D. Dubey
» doi: 10.48047/ecb/2023.12.si4.496

Abstract

Polyphenols and flavonoids constitute a class of copious secondary metabolites found in numerous plant sources. Various biological properties, including anti-inflammatory and anti-allergic effects, have been attributed to them, making them a potential candidate for the treatment of asthma. To comprehend the mechanism behind their antiasthmatic activity and enhance their efficacy, structure-activity relationship (SAR) research has been conducted. According to SAR investigations, the presence of hydroxyl groups on the B- and C-rings of flavonoids is essential for their anti-inflammatory and anti-allergic properties and anti-allergic effects, have been attributed to them, making them a potential candidate for the treatment of asthma. To comprehend the mechanism behind their antiasthmatic activity and enhance their efficacy, structure-activity relationship (SAR) research has been conducted. According to SAR investigations, the presence of hydroxyl groups on the B- and C-rings of flavonoids is essential for their anti-inflammatory and anti-allergic properties. The degree of hydroxylation and the location of the hydroxyl groups are crucial in determining the flavonoid's activity. Important for the activity is the presence of a catechol or pyrogallol group in the B-ring. In contrast, the presence of hydroxycinnamic acid in the structure of polyphenols is crucial for their activity. SAR studies also indicate that the substitution pattern and location of the hydroxyl groups on the cinnamic acid moiety are crucial for the activity of polyphenols. These SAR studies have yielded insights into the mechanism underlying the antiasthmatic activity of polyphenols and flavonoids, which could aid in the development of more effective natural treatments for asthma.

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