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ISSN 2063-5346
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The percentage levels of haemoglobin variants in Sickle Cell Anemia children from Western Maharashtra

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Dipali Gautam Marchande, Dr. Deepali Vidhate, Dr. V W Patil
» doi: 10.31838/ecb/2023.12.si4.231

Abstract

Sickle-cell anemia (SCA) is the first monogenic genetic disorder in the world, affecting 20 – 25 million people with SCA worldwide. Present work was undertaken to measure the levels of Hb, HbF, HbA0, HbA2 and HbS in sickle cell anemia and healthy children. Aim & Objectives: Study was undertaken to determine the percentage levels of Hb Varients in children’s with SCA and Healthy Children’s. Material & Methods: In this case control study a total 200 subjects were recruited after obtaining written inform consent. All subject visiting OPD between the age group of 1-12 yrs. were randomly selected and grouped as healthy (control group) (n = 100), HbSS positive (n = 100) (Study group). Healthy subjects were age and sex matched with study HbSS patients. We used whole EDTA blood, the levels of HbF, HbA0, HbA2 and HbS were determined by ion-exchange High Performance Liquid Chromatography (HPLC) method. Results: SCA patients had significantly increased levels of HbS (p<0.001), HbF (p<0.001), HbA2 compared to control. It was observed that the mean levels of HbA0 were significantly less than control Group. Conclusion: High percentage of HbS, HbF HbA2 and the low percentage of HbA0 found in sickle cell Anemic children’s of Maharashtra, thus in toto due to high level of naturally compensated HbF and HbA2 leads to benefit the longevity of life of HbSS Children

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