The Neurodegenerative disease which pushes heart disease to second place due to severe health disorders is Alzheimer’s disease. The main pathological emblem identified is the Cholinergic hypothesis and the Amyloid-Beta hypothesis. The currently available medications can be used to manage the disease and these synthetic medicines are working as per the Cholinergic hypothesis. The recently FDA- approved biological medicine Aducanumab which is an amyloid beta-directed monoclonal antibody which reduces amyloid beta plaques. Alternatively, many plants which are in traditional use as well as in multi-cuisine also help to manage the disease. The mechanism of action of phytomedicines which were identified from medicinal plants for neuroprotective activity is ongoing research. This Review discusses the neuroprotective properties and the probable mechanism of the plants consumed in day-to-day south India.