Schiff bases are a group of compounds prepared by the condensation of primary amines and active carbonyl compounds. The Schiff bases have a general structure RRʹC=N-Rʹʹ (where R, R’ and Rʹʹ are alkyl, cyclohexyl, hydroxyalky1, hydroxyary1, etc). Herein the different synthetic routes of Schiff Base complexes like, direct synthesis, in situ method, oxidation of coordinated secondary amine, amine exchange approach, metal exchange and ligand exchange reaction are reviewed. A concise survey of literature on the coordination modes of complexes of Schiff base ligands is also presented in this article. The coordination complexes have been successfully screened against different strains of bacteria where they depicted the potential antimicrobial behaviour.