.

ISSN 2063-5346
For urgent queries please contact : +918130348310

SYNTHESIS OF CHROMANONES AND FLAVONES LEADING TO THE SYNTHESIS OF NEW INDAZOLE DERIVATIVES AND EVALUATING ITS BIOLOGICAL ACTIVITY

Main Article Content

Brijesh Kumar N. Singh1*, Onkar Lotlikar2
» doi: 10.31838/ecb/2023.12.si5.053

Abstract

The chromanone formation starting from 2-phenyl-4-formyl-2H-1,2,3-triazole (1) with 2-hydroxy acetophenone under basic condition was done to achieve the α, β-unsaturated ketone i.e., the chalcone viz., 1-phenyl-3-(2-phenyl-2H-1,2,3-triazol-4-yl)-2-propene-1-one (2). This compound on cyclization under acidic condition yielded a flavone (8) containing 2-phenyl-2H-1,2,3-triazole as substituent. Further, this compound (2) on reacting with ethyl aceto acetate gave 3-(2’-Hydroxyphenyl)-5-(2-phenyl-2H-1,2,3-triazol-4-yl)6-carbethoxy cyclohex-2-en-1-one (3) which on treatment with hydrazine yielded the corresponding oxoindazole (4) the target compound i.e., 4-(2-Phenyl-2H-1,2,3-triazol-4yl)-6-(2-hydroxyphenyl)-3,3a,4,5-tetrahydro-3(2H)-oxoindazole (4) in good yield.

Article Details