The development of drug delivery systems that can provide controlled release of drugs is an important area of research in the pharmaceutical industry. The use of natural polymers, such as guar gum, as excipients in drug formulations has gained significant attention due to their biocompatibility, biodegradability, and low toxicity. In this study, galactomannan esters, namely guar acetate and guar acetate maleate, were synthesized from guar gum and their release retardant properties were compared. Guar acetate maleate was found to be a more effective release controlling excipient compared to guar acetate due to its pH-dependent drug release behaviour. The drug-polymer compatibility study showed that there was no interaction between the synthesized polymers and diclofenac sodium, indicating that the polymers can be used as release controlling excipients. The in vitro dissolution studies revealed that the drug release was pH-dependent, with the drug being released only in basic pH. This property of the synthesized polymers can be utilized to develop enteric-coated tablets, which can protect the drug from the acidic environment of the stomach and release it in the alkaline environment of the small intestine. The use of natural polymers in drug delivery systems has several advantages over synthetic polymers. Natural polymers are biocompatible, biodegradable, and non-toxic, which makes them suitable for use in biomedical applications. Additionally, the use of natural polymers can reduce the environmental impact associated with synthetic polymers. In conclusion, the synthesized galactomannan esters, guar acetate, and guar acetate maleate, demonstrated controlled release properties and can be potentially used in the development of novel drug delivery systems. The use of natural polymers in drug delivery systems can provide a safer and more sustainable alternative to synthetic polymers