Colorectal cancer is fourth most common cancer worldwide . In India, Annual incidence rates for colon cancer and rectal cancer in men are 4.4 and 4.1per 100000 respectively. The aim of this study was to study the correlation of final histopathology specimen (pathological tumor regression grade) with preoperative MRI (magnetic resonance tumor regression grade) (mrTRG). Materials and Method: A total of 158 patients who satisfied the inclusion and exclusion criteria were included in the study. Patients with early stage (T1, 2 or N0) underwent upfront surgery in the form of LAR or APR and patients with locally advanced cancer (T2N+, T3N0/N+, T4N0/N+) were subjected to NACRT before surgery. Results: The good pathological response was found in 28 patients. They had undergone NACT with a pTRG score of 3 and 4. Poor pathological response was seen in 110 patients with score of 1 and 2. Out of 138 patients who had underwent the process of neoadjuvant CT/RT before surgery, the good response with mrTRG score 1 and 2 was found in 48 patients and intermediate response was seen in 78 patients with mrTRG score of 3 and poor response with mrTRG score of 4 and 5 was found in 12 patients. Conclusion: Colorectal cancer is a disease originating from the epithelial cells lining the colon or rectum most frequently as a result of mutations in the Wnt signaling pathway that increase signaling activity. Present study concluded that mrTRG is good predictor of pathological response and thus a prognosticator of completeness of resection. So, efforts should be made to do a mrTRG scoring in each patient as it not only provides oncological safety but also reduces post operative mortality.