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ISSN 2063-5346
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STUDY OF SNAKE BITE INDUCED COAGULOPATHY AMONG HOSPITALIZED PATIENTS IN RELATION TO ACTIVATED PARTIAL THROMBOPLASTIN TIME AND PROTHROMBIN TIME

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Dr. Sushrut Patil, Dr Aparna Patange, Dr Pratiksha Jadhav, Dr.Rucha Shetti, Dr.Saketh Reddy
» doi: 10.31838/ecb/2023.12.s2.074

Abstract

Snakes are distributed throughout most of the earth’s surface with some exceptions such as the Arctic, Antarctic, and many in small islands. Indian states with high incidence of snakebites cases are Tamil Nadu, West Bengal, Maharashtra, Uttar Pradesh, and Kerala. The main Aim:of this study is to analyse outcome of patients with alleged history of snake bite with respect to coagulation parameters activated partial thromboplastin time and prothrombin Time. Material and methods: Present study was a single center hospital based prospective, observational descriptive study. Conducted in patients admitted to Medical Intensive Care Unit of Krishna Institute Medical Sciences, Karad, over a period of 18 months from November 2020 to April 2022. Total 100 cases were studied. Data analysis: The collected data was compiled in Microsoft Excel 2010. Data describing quantitative measures was expressed as mean, median, mean + SD, standard deviation. Results: The mean age of study population was 32.2+ 11.6 years, ranging from 17 to 64 years. A majority of patients belonged to age group of 21-40 years (59%). A total of 24% were in age group more than 40 years age, while 17% were in age group 15-20 years. A total of 48 patients had reached the hospital within 30 to 60 minutes (48%).There were 38 patients who had reached after 60 minutes (38%). A total of 14% patients reached within 30 minutes. Both these tests APTT and PT are used as measure for clotting pathways in blood. A total of 68 % of the patients had prolonged prothrombin time and a total of 64% patients had prolonged Activated partial thromboplastin time. There was statistical significance between development of complications and prolonged activated partial thromboplastin time, prolonged prothrombin time as P value < 0.01. Conclusion: Present study concludes that there is a significant correlation of prolonged Prothrombin time and Activated Partial Thromboplastin time with morbidity and mortality in patients with alleged history of snake bite and treating physicians should monitor such patients carefully in order to prevent complications associated with it.

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