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ISSN 2063-5346
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STUDY OF PHYSIOCHEMICAL & SOLUBILITY PROPERTIES OF ACELOFENAC USING FTIR

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Lalit Bisht, Dr.Nandu Rangnath Kayande
» doi: 10.31838/ecb/2023.12.si4.245

Abstract

The aim of this study was to improve the dissolution and release rate of Aceclofenac drug in controlled manner over a period of 24 h. Matrix tablets were prepared by direct compression method, using hydrophilic polymers (HPMC/ guar gum). Matrix tablets were prepared by wet granulation method using different concentration of hydrophilic polymers (HPMC/ guar gum).Tablets were evaluated for in-vitro drug release profile in phosphate buffer, pH 6.8, (without enzymes).Drug release was retarded with an increased in polymer concentration due to the gelling property of polymers. The in-vitro drug release from proposed system was best explained by the Higuchi’s model indicating that the release of drug from tablets displayed diffusion controlled mechanism. Aceclofenac is used in the management of pain and inflammation. The drawback encountered with the conventional tablet dosage forms of aceclofenac are poor aqueous solubility, extensive first pass metabolism. Hence to overcome these issues, the dosage form may be designed in form sustained release formulation to improve its dissolution and bypassing hepatic first-pass effect. Hence the aim of the present study was to prepare and evaluate sustained release matrix tablet of Aceclofenac, tablets were prepared by direct compression by using hydrophilic polymers (HPMC/ guar gum).

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