Stroke is the second leading cause of death globally and is associated with up to 5.54 million deaths every year, two thirds of which occur in resource poor countries. Cerebro vascular accidentalso called as stroke is defined as the sudden onset of neurological deficit that can be attributable to a focal vascular cause. Acute ischemic stroke is characterized by the sudden loss of blood circulation to an area of brain, resulting in a corresponding loss of neurologic function. acute ischemic stroke is caused by thrombotic or embolic occlusion of a cerebral artery. Clinical stroke scores are proposed to differentiate between stroke subtypes but their reliability is unknown. Cerebrovascular Accident or stroke is a major cause of morbidity and mortality. For any treatment to be contemplated it is important to know whether we are ealing with a bleed or an infarct. Aim:To study of Electrocardiogram and 2-Dimensional Transthoracic Doppler Echocardiogram changes in patients with acute ischemic stroke. Material and methods:The study was conducted at KRISHNA INSTITIUE OF MEDICAL SCIENCES ON 96 patients who inclusive fulfill the criteria’s were chosen as study subjects.Patients who are admitted in Intensive Care Unit at Krishna hospital were included in the study. Electrocardiogram and 2-Dimensional Transthoracic Doppler Echocardiogram was assessed in the patients of stroke within 72 hours of admission.After admission a detailed history and clinical examination was carried out in all the cases of acute ischemic stroke. The diagnosis of Acute ischemic stroke was made on the basis of Clinical examination and CT scan of brain of the patients. The collected data was compiled in Microsoft Excel 2010. Data was analyzed using SPSS (Statistical Programme for Social Sciences) software 21 version, OpenEpi Software Version 2.3. Results: Total 96 patients with acute ischemic stroke were included in this prospective observational study, of which [68 (70.8%)] were males and [28 (29.2%)] were females. This study was predominated by the male gender with a male to female ratio of 2.42:1. A majority of the patients belonged to the age group of 61 to 80 years (43.75%), followed by 41 to 60 years (35.42%). The minimum age of the patients was 22years, and the maximum age was 62 years. Conclusion:In present study ST-segment depression and ‘T’ wave abnormalities were frequent Electrocardiogram abnormalities and as Left Ventricular Dysfunction (LVD) was frequent Echocardiogram abnormalities. This gives clue for risk factors of Atherosclerotic cardiovascular disease (ASCVD) like Hypertension, Diabetes Mellitus for risk stratification strategy. Common risk factor profile for Acute Ischemic Stroke (AIS) and Coronary Artery Disease (CAD) are also easily evaluated by Electrocardiogram and Echocardiogram.