Due to its diverse applicability in the realm of medicine, the heterocyclic fused nucleus quinazoline has attracted a lot of attention in recent years research in chemistry. A number of patents and studies on the discovery and development of novel potential quinazoline compounds have been published in the literature. Quinazoline and their derivatives are a type of chemical substance that is very prevalent. Chemicals that are the most active and have a wide variety of biological effects actions such as antibacterial, antifungal, and antiviral properties antifungal, anti-HIV, analgesic, antimicrobial, anti-inflammatory, anticancer, and antihypertensive antioxidant, analgesic, anticonvulsant, anti-malarial, anticancer, and anti-tubercular properties. The goal of this review was to compile research on Quinazoline for its diverse pharmacological effects described by researcher’s activities, as well as recent attempts on this subject.