Obsessive-compulsive disorder (OCD) is a reasonably common mental illness that has a serious impact on the community's health. Although many patients find current conventional drugs to be effective, they can also have a variety of side effects. A variety of anxiolytic qualities have been found in substances derived from plants that have been tested for various mental diseases. We conducted a systematic evaluation of the pharmacological and clinical evidence of herbal medications and phytochemicals with antiobsessive-compulsive effects using the electronic databases PubMed, Scopus, and the Cochrane Library up to June 12, 2019, to assess the state of the evidence in the field. For the purpose of locating studies on the underlying mechanisms of action, additional search criteria were used. Results showed that numerous plant remedies, including Crocus sativus, Citrus aurantium L., Silybum marianum,Withania somniferaand Echium, have some tentative low-quality evidence.