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ISSN 2063-5346
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REVIEW ON VARIOUS SPECTROSCOPIC METHODS OF MEFENAMIC ACID AND RABEPRAZOLE

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Nagi Simran Harminder Singh
» doi: 10.48047/ecb/2023.12.si5a.037

Abstract

Mefenamic acid (MFA) is a non-steroidal anti-inflammatory drug that belongs to the anthranilic acid derivative family. It is used to relieve mild to moderate pain. Rabeprazole (RBP) is an proton pump inhibitor which inhibits gastric acid secretion. Proton-pump inhibitors (PPIs) have been proven efficacious in healing NSAIDassociated ulcers, as they provide potent and long-lasting inhibition of gastric acid secretion. The present review article includes a compilation of articles on the various properties along with an extensive literature survey on the reported analytical methods of MFA and RBP. Using a comprehensive computer assisted literature review; this article discusses the analytical methodologies for quantifying MFA and RBP both in active pharmaceutical ingredient and pharmaceutical dosage forms. This is the first review article in this series with focus on the analytical profile of MFA. This review focuses on several methods like High Performance Liquid Chromatography (HPLC), Thin Layer Chromatography (TLC), spectrophotometry, fluorimetry, turbidimetry, Atomic Absorption Spectroscopy (AAS), Mass Spectroscopy (MS) and electro analytical methods of MFA and RBP.

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