Overview of non-steroidal anti-inflammatory medications (NSAIDS), whose prescribing trends have changed significantly worldwide. They are regarded as being quite efficient in managing a variety of illness situations, such as gastrointestinal bleeding, CVS cardiovascular, inflammation, and pain. These negative effects are typically exacerbated when NSAIDS are taken along with other medications that have similar negative effects and toxicity. These NSAIDS that inhibit cyclo-oxygenase (cox-1 and cox-2) enzymes are a family of drugs that exhibits higher therapeutic efficacy, stability, and safety. NSAIDs are typically divided into groups based on their chemical structure and selectivity: acetylated salicylates (aspirin), non-acetylated salicylates (diflunisal, salsalate), propionic acids (naproxen, ibuprofen, acetic acids (diclofenac, indomethacin), enolic acids (meloxicam, piroxicam) anthranilic acids (meclofenamate, mefenamic acid), naphthylalanine (nabumetone), and selective COX-2 inhibitors (celecoxib, etoricoxib). NSAIDs have analgesic, antipyretic and anti-inflammatory activity. Antipyretic activity is exerted by inhibiting the rise of levels of PG in the brain, which acts as pyrogens, acting directly on the thermo-regulatory center in the hypothalamus, to increase body temperature. Their analgesic and anti inflammatory effect is due to inhibition of PG synthesis in the inflammed tissues and therefore is on a peripheral level. PG cause little pain themselves but potentiate the pain caused by other mediators with bradykinin and histamine.