The aim of this study was to assess the influence of Pieplant and milk vetch intake considering inflammation markers, visceral fats, Leptin hormone and antioxidant enzymes on male overweight rats. Histological changes of liver and kidneys, phenol fraction of Pieplant and milk vetch was also in the scope of this investigation. A total number of thirty five adult male rats of the strain Sprague Dawley were involved via distribution on 5 groups being: Control (-) fed on regular basal diet, Control (+) rats fed on HFD, overweight rats fed on 5% Pieplant diet, overweight rats fed on 5% milk vetch diet, and overweight rats given a diet with 5% of both plant material. After 28 days of feeding intervention rats were sacrificed