Oral lichen planus (OLP) is a chronic disease of established immune-mediated pathogenesis. It mostcommonly, protractedly, and persistently involves the mucosa of the oral cavity. Antigen-specific and nonspecificmechanisms play a role in its pathogenesis, leading to T-cell accumulation in superficial lamina propria, intraepithelial T-cell migration, and keratinocyte apoptosis in OLP. In recent control studies, antihepatitis C virus (anti-HCV) circulating antibodies were more common in patients with lichen planus than in controls.The controversies and uncertainties regarding the association of HCV and the liver function status (transaminase levels) in oral lichen planus transpired this study design and implementation. Aims: To determine andcompare the serum transaminase levels and anti HCV status in OLP patients and healthy controls, to inquire into the possible association of OLP and to determine if the clinical characteristics of OLP differed with alterationsin serum transaminase profile patterns. Subjects and Methods: Forty patients comprising 20 cases and 20 controls were enrolledfor the study. Twenty cases of clinically and pathologically diagnosed OLP and twenty age- and sex-matched controls weresubjected to blood examination for the assessment of serum transaminase level, i.eSGPT and SGOT. Theobtained data were compared with standard values to assess any alterations of the serum transaminase levels. Further, the anti HCV status was assessed in in patients demonstrating elevation of serum profile. Statistical Analysis used Pearson’s correlation and student’s unpaired t-test. A P ≤ 0.05was considered statistically significant. Results: Pertainingto individual serum lipid levels in cases and controls, the association was found to be statistically insignificantand the anti HCV status was negative in the entire selected sample. Conclusions: The current study suggested an evident association between elevated serum transaminase levels and OLP; elevated levels were significator for severity of OLP symptoms. We recommendimminent studies on a larger population of geographical interest to additionally substantiate a positive association between the two.