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ISSN 2063-5346
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RECENT ADVANCEMENTS IN THE DEVELOPMENT OF PROBIOTICS AS PHARMACEUTICALS: A REVIEW

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Geethika Harikumar, Subham Jain, Praveen Halagali, Shailesh T, Prasanna Srinivas Deshpande , Hemanth Kumar S
» doi: 10.31838/ecb/2023.12.si4.209

Abstract

Probiotics are live microorganism used to improve microbial balance in gastrointestinal tract. Probiotics have a long history of traditional use. Recently, probiotic products are gaining popularity in the last two decades because of scientific evidence showing their synergistic effect on humans. The mechanism of probiotics is diverse, strain-specific, and heterogeneous, which have received the attention on scientific development and research. This review aims to discuss the needs, health benefits with a main emphasis on pharmaceutical interventions done to improve the viability of probiotics as pharmaceutical dosage forms such as capsules, enteric coated tablets and encapsulation techniques. A brief review of available patents, market capture of the probiotic and its potential in the future, the use of probiotic as immunomodulators during the COVID-19 pandemic, and clinical trials happening in the field of probiotics are also discussed.Through the pharmaceutical approach, probiotics can be delivered efficiently and the viability can be maintained throughout the products shelf life.The production of effective probiotic products will rely both on evidence of a probiotic effect and on the development of products that, at the time of consumption, shelter high numbers of viable species. To increase the efficacy of the probiotics, there is a need for pharmaceutical intervention in terms of formulation manipulations. Persistent experimental studies focused on understanding the health-promoting effects of probiotic bacteria at a molecular level be a key focusing aspect.

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