Novel drug delivery system have emerged various route of administration, among all the drug delivery system oral drug delivery system is most favourable drug delivery system. A lipid base drug delivery system is one of positive approach for Poorly water soluble drugs. Based on Lipid vesicular system like liposomes, proniosomes and niosomes have been developed. Aim of present study to developed Clozapine based proniosomes to enhance solubility and bioavaibility of the drug. Clozapine loaded Proniosomes prepared by the slurry method using different ration of Cholesterol: span 60 and Mannitol as a carrier. Respectively were continuously compressed into tablet using direct compression method. Proniosomes was evaluating for Particles size, Micromertic properties, entrapment efficiency, and dissolution. Proniosomal tablets showed improve dissolution characteristics over the plain tablets which were improve dissolution behaviour. The Transformation of crystalline form to the amorphous was represented by the solid state characteristics.