Herbs have been used by humans for thousands of years as a source of food and medicine. Indigenous people from tropical regions have been found to use various parts of the Sida spices plant to treat a wide range of health issues, including rheumatic affections, azoospermia, oligospermia, and spermatorrhea, leucorrhoea, wounds, sciatica, nervous and heart diseases, colds, cough, asthma, tuberculosis, and respiratory diseases, diseases of the blood, and bil Alkaloids, saponins, saponin derivatives, coumarins, steroids, tannins, phenolic compounds, cardiac glycosides, sesquiterpene, and flavonoids, all of which are present in significant amounts in the plant extract, are thought to be responsible for the plant's wide range of properties and applications in traditional medicine. The objective of this review research is to provide a thorough evaluation of the literature on the ethnomedicinal applications, phytochemical and pharmacological profiles, and toxicity of Sida spices.