Depression is one of the most crucial reasons of disability in adults. The incidence of depression is about 3-10 % in general. Depression is much prolong the patients have chronic diseases. Depression is a neurological disorder that leads to changes in mood, thoughts, behavior and physical health. Celosia cristata Linn (Amaranthaceae) is used in traditional medicine for the treatment of headache, sores, ulcers, eye inflammations, skin eruption, painful menstruation and carpal tunnel syndrome. The aim of present study was to investigate the antidepressant activity of petroleum ether and hydroalcoholic extract of leaves and flowers of Celosia cristata Linn in albino wistar rats by Forced swimming test. Acute toxicity of the extract (2000 mg/kg) was examined in wistar rats for 14 days. Qualitative analysis of various phytochemical constituents and quantitative analysis of total phenolics and flavonoids were determined by the well-known test protocol available in the literature. Phytochemical analysis of hydroalcoholic extract of leaves and flowers extract revealed the presence of carbohydrates, alkaloids, flavonoids, tannins and phenolic compounds, protein and amino acids, glycosides. The total phenolics content of hydroalcoholic extract of leaves and flowers extract of Celosia cristata was (79.00 mg/gm and 47.00 mg/gm equivalent to Gallic acid), followed by flavonoids (44.00 mg/gm and 23.00 mg/gm equivalent to Rutin), respectively. Extract up to 2000 mg/kg did not produce any toxic effects. It was observed that there was significant reduction (p<0.05) in immobility time in group (CCLHAE 400mg/kg) and group (CCFHAE 400mg/kg) treated group when compared to stress induced showing their potent antidepressant action. Similarly, Imipramine group (30mg/kg) showed significant reduction in immobility time (p< 0.05). The present study suggested that Celosia cristata possessed potential antidepressant effects which could be of therapeutic interest for using in the treatment of patients with depression.