The Bioactive Compounds of Cathantanthus Roseus. L have been analyze dusing Gas Chromatography - Mass Spectrometer (GC-MS). The Chemical compositions of the whole plant volatile compounds in Ethanol and water extracts of Cathantanthus Roseus.L of Rosea and Albawere analyzed through GC-MS. Majority of the compounds were belonging to ester and acid groups.1, 2-Benzene dicarboxylic acid diethyl ester was the higher percentage metabolite in Cathantanthus Roseus. L of Rosea and Alba. The bioactive compounds identified in the ethanolic extract of samples in both the varieties are Salicylic acid methyl ester, Salicylic acid ethyl ester, Myristic acid, Palmitic acid, Palmitic acid ethyl ester, Phytol, Linolenic acidmethy l ester, Linoleic acid ethyl ester, Linoleic acid and Linoleic acid ethyl ester. All these compounds are having antioxidant property with anti-inflammatory and anti cancer properties. The water extract analysis of plants showed the presence of Alkaloids in both the varieties which are very good antioxidants and anti-inflammatory compounds. Bioactive compounds are more in ethanolic extract of plants than in water extracts.