The aim of work is process optimization of a milling plant in order to minimize sucrose loss with final bagasse as another option. The experiment was carried out with design expert software. By identifying main factors i.e. imbibitions of water and hydraulic pressure effect on response variable i. e percentage sucrose in bagasse, it was applied to the process optimization in order to get the optimum process condition in which the sucrose loss is minimum. This is achieved at maximum imbibitions of water (62.6 m3 h-1) and maximum hydraulic pressure (110 kg cm-2). Under these optimum conditions, the minimum sucrose in bagasse is 3.4 % unit. This results in sucrose saving of 0.04 ton h-1