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ISSN 2063-5346
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NOVEL BRONSTED ACIDIC IONIC LIQUID L-PYRROLIDINE- 2-CARBOXYLIC ACID SULFATE: AN EFFICIENT AND ECOFRIENDLY CATALYST FOR SYNTHESIS OF 2,4,5- TRISUBSTITUTED-1H-IMIDAZOLES UNDER SOLVENT FREE CONDITIONS

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V. W. Godse[a], S. N. Darandale[b], S. S. Rindhe[c], Y. R. Parandkar[b], R. D. Desai[b], B. H. Zaware[b], S. S. Jadhav[b] and R. P. Pawar
» doi: 10.17628/ECB.2016.5.280

Abstract

A simple, highly efficient and eco-friendly protocol for the synthesis of bioactive 2,4,5-trisubstituted-1H-imidazoles via one-pot three component condensation of benzil, aromatic aldehydes and ammonium acetate under solvent free conditions has been achieved utilizing the novel Bronsted acidic ionic liquid, (L-pyrrolidine-2-carboxylic acid sulfate) as catalyst. The distinguishing features of this methodology are excellent yields in shorter reaction time, cleaner reaction profile, and environmentally friendly nature, use of non-toxic, easily synthesizable, inexpensive catalyst.

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