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ISSN 2063-5346
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Novel analytical method development for estimation of Remdesivir in bulk byusing Bromocresol purple- Acid dye

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R. Karthikeyan1, VijaykumarSayeli2,V.Vijayan1, BinoyVargheseCheriyan3, M.Sumithra4,Semmal Syed Meerasa5,M. Sakthiganapathi1, G. Haema1, V.Abishek6
» doi: 10.48047/ecb/2023.12.5.081

Abstract

A simple UV spectrophotometric method has been developed for the quantitative estimation of remdesivir (REM) by complex formation with an acid dye bromocresol purple (BCP). This method involves the formation of a yellow-coloured ion-pair complex ofbromocresol purplereagent with remdesivir using chloroform at pH 2.The resultant complex was measured at itsλmax of 420 nm. Beer Lambert’s range was found to be 4 to 12 μg/ml with a good correlation coefficient (R2= 0.9977).The proposed method was validated as per ICH guidelines.The developed method has been used for the determination of remdesivir in bulk and can be adaptedfor pharmaceutical formulations.

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