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ISSN 2063-5346
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DESIGN, FORMULATION AND CHARACTERIZATION OF MICROCAPSULES OF NSAID DRUG

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Dr. Ashutosh Badola1 , Ankita Negi
» doi: 10.48047/ecb/2023.12.si5a.057

Abstract

Microencapsulation is a technology that involves the production of small, spherical particles called microcapsules that are designed to enclose a material or substance within a protective shell. This technology has gained popularity in recent years due to its numerous applications in different fields. Pharmaceutical, cosmetic, agriculture and other fields are using microencapsulation as new approach to improve the stability, shelf-life, and bioavailability of different substances. This paper showed formulation of microencapsulation, their advantages and disadvantages, and the various applications of microencapsulation. Beside conventional microcapsules, it also encompasses self assembling structure and other particulate requiring preparative manipulation. This paper provides an overview of encapsulation materials, the mechanism of release through the capsule wall and preparation techniques, and the numerous applications to which microcapsules can be applied. NSAIDs are pain relieving drugs which are used to treat arthritis pain and also for body aches, swelling, stiffness. When core materials are surrounded by Microcapsules of Etoricoxib were prepared by solvent evaporation method by using different drug-polymer ratio with different solvent. Prepared microcapsules were evaluated for the particle size, percentage yield, incorporation efficiency, flow property and in vitro drug release. From the result we can conclude that as the concentration of polymer increases, it affects the particle size, percentage yield and drug release of microcapsules. And different shape of microcapsules had seen with different solvent (Chloroform, Dichloromethane, Acetone) and polymer (HPMC, 2-Hydroxypropyle-beta cyclodextrin, Polyvinyl alcohol). The excellent flow properties, particle size, percentage yield (93.24%), incorporation efficiency (95.69%) and percentage drug release (96.88%) showed by F6 for a period of 15 hrs. Results of the present study indicate that Etoricoxib microcapsules can be successfully designed to offer protection and enhance the bioavailability.

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